SCIENTIFIC OUTPUT

 

BIBLIOGRAPHY

The CRN has compiled the published cancer research conducted at our sites over the past 20 years.

Click here to view more than 1500 peer-reviewed scientific research articles in our PubMed collection on MyNCBI. To search within this collection, click on "Advanced" once you get to PubMed and use the builder tool to add search terms.

 

List of select descriptive CRN papers:

 

EXEMPLAR STUDIES

 

PROSPR: Optimizing Colonoscopy & FIT tests for Community Based Screening U54CA163262
Contact PI - Doug Corley  
   Screening can reduce colorectal cancer incidence and mortality in clinical trials. However, the real practice of screening in a community-based population differs from what can be achieved in trials. Optimizing screening strategies by characterizing potential failures of the screening process and developing screening strategies tailored to personal risk offer substantial potential for decreasing colorectal cancer deaths.  
Involved Sites: KP Northern California, KP Washington, University of Texas Southwestern  
   
Infrastructure for Pathways, A Prospective Study of Breast Cancer Survivorship U01CA1195565
Contact PI - Larry Kushi  
     The Pathways Study is a prospective cohort study of 4,505 women diagnosed with invasive breast cancer in Kaiser Permanente Northern California (KPNC), with data on lifestyle and psychosocial factors, blood samples and extracted DNA, and linkage to KPNC medical records and neighborhood social and built environment databases. In this infrastructure grant, we are enhancing the Pathways Study resource by continuing to follow study participants and documenting outcomes; enhancing biospecimen resources with a tumor biobank and creation of tissue microarrays; and by adding new data from KPNC medical records, genome-wide assays, and neighborhood characteristics. These activities make the Pathways Study an outstanding and unique resource for research on breast cancer survivorship and prognosis.  The Pathways Study welcomes collaborations with others interested in studies of breast cancer prognosis and outcomes.   

Involved Sites: KP Northern California, Roswell Park Comprehensive Cancer Center, UCSF, Zero Breast Cancer.

Collaborative studies have been conducted or are ongoing with institutions such as: KP Washington, City of Hope Comprehensive Cancer Center, Columbia University, Georgetown University, Fred Hutchinson Cancer Research Center, and Memorial Sloan Kettering Cancer Center.

 
   
Risk of Pediatric and Adolescent Cancer Associated with Medical Imaging R01CA185687
Contact PI - Rebecca Smith Bindman  
   The use of medical imaging that delivers ionizing radiation is high in the United States. The potential harmful effects of this imaging must be understood so they can be weighed against its diagnostic benefits, and this is especially critical for our vulnerable populations of children and pregnant women. The proposed study will comprehensively evaluate patterns of medical imaging, cumulative exposure to radiation, and subsequent risk of pediatric cancers in four integrated health care delivery systems comprising over 7 million enrolled patients enrolled from 1996-2017.  
Involved Sites: Geisinger Health System, HealthPartners, KP Northern California, KP Southern California, KP Northwest, KP Washington, Marshfield Clinic, University of Toronto, UCSF, and UC Davis.
 
   
Obesity, Chemotherapy Dosing and Breast Cancer Outcomes R01CA222793
Contact PI - Elizabeth Kantor  
   Epidemiologic studies have linked obesity to poor breast cancer outcomes, and it has been suggested that obese women may experience poorer outcomes, in part, due to dose reductions of chemotherapy drugs; this is because most cytotoxic agents are dosed according to body size, and clinicians may scale back the high doses administered to obese women due to concern about inducing toxicity. Given persisting uncertainty about dosing obese women, in a study population of nearly 34,000 women with breast cancer who were diagnosed and treated in two integrated healthcare delivery systems, Kaiser Permanente Northern California and Group Health, we propose to: i) examine the relationship between body size and dose intensity, and will further examine how the factors contributing to dose reductions vary by body size, ii) evaluate whether chemotherapy dose reductions mediate the associations between obesity and adverse breast cancer outcomes, and iii) evaluate the association between body size and toxicity among women identified as receiving the full body-size determined dose of chemotherapy. Addressing these questions will provide the evidence needed to better inform clinicians treating the 102,000 obese women diagnosed with breast cancer each year in the United States.  
Involved Sites: Memorial Sloan Kettering Cancer Center, KP Northern California, KP Washington, Rutgers Cancer Institute of New Jersey
 
   

RESEARCH PROJECT PORTFOLIO

The CRN has facilitated hundreds of research collaborations: supporting the Scholar's Program, funding pilot and developmental projects, connecting external collaborators, and more. Download a list of titles using the link below. Last updated: March 2018

[link to spreadsheet forthcoming]